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Cellosaurus U-2OSMR (CVCL_A5VB)

[Text version]
Cell line name U-2OSMR
Synonyms U-2OS(MR)
Accession CVCL_A5VB
Resource Identification Initiative To cite this cell line use: U-2OSMR (RRID:CVCL_A5VB)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line

PubMed=19638450; DOI=10.1158/1535-7163.MCT-09-0115
Duan Z.-F., Choy E., Harmon D., Yang C., Ryu K., Schwab J.H., Mankin H.J., Hornicek F.J.
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.
Mol. Cancer Ther. 8:2122-2130(2009)

PubMed=25236161; DOI=10.1186/1471-2407-14-681
Duan Z.-F., Zhang J.-M., Ye S.-N., Shen J.K., Choy E., Cote G.M., Harmon D., Mankin H.J., Hua Y.-Q., Zhang Y., Gray N.S., Hornicek F.J.
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
BMC Cancer 14:681.1-681.11(2014)

Encyclopedic resources Wikidata; Q107117156
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number5