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Cellosaurus U-2OSMR (CVCL_A5VB)

[Text version]
Cell line name U-2OSMR
Synonyms U-2OS(MR)
Accession CVCL_A5VB
Resource Identification Initiative To cite this cell line use: U-2OSMR (RRID:CVCL_A5VB)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=19638450; DOI=10.1158/1535-7163.MCT-09-0115; PMCID=PMC2766237
Zhen-Feng Duan, Edwin Choy, David C. Harmon, Cao Yang, Keinosuke Ryu, Joseph H. Schwab, Henry J. Mankin, Francis John Hornicek;
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines.
Mol. Cancer Ther. 8:2122-2130(2009)

PubMed=25236161; DOI=10.1186/1471-2407-14-681; PMCID=PMC4177239
Zhen-Feng Duan, Jian-Ming Zhang, Shu-Nan Ye, Jacson K. Shen, Edwin Choy, Gregory M. Cote, David C. Harmon, Henry J. Mankin, Ying-Qi Hua, Yu Zhang, Nathanael S. Gray, Francis John Hornicek;
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
BMC Cancer 14:681.1-681.11(2014)

Cross-references
Encyclopedic resources Wikidata; Q107117156
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number6