Cellosaurus cell line S2:DER2f (CVCL

Cross-references
Cell line name	S2:DER2f
Synonyms	D2F; D2f; DER2-expressing S2 cells; D2R
Accession	CVCL_A5UZ
Resource Identification Initiative	To cite this cell line use: S2:DER2f (RRID:CVCL_A5UZ)
Comments	Group: Insect cell line. Genetic integration: Method=Transfection/transduction; Gene=FlyBase_Gene; FBgn0000434; Der. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
Species of origin	Drosophila melanogaster (Fruit fly) (NCBI Taxonomy: 7227) Breed/subspecies: Oregon-R; FlyBase_Strain=FBsn0000276.
Hierarchy	Parent: CVCL_Z232 (Schneider 2)
Sex of cell	Male
Age at sampling	Late embryonic stage
Category	Spontaneously immortalized cell line
Publications	PubMed=7601354; DOI=10.1101/gad.9.12.1518 Ronen Schweitzer, Miriam Shaharabany, Rony Seger, Ben-Zion Shilo; Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9:1518-1529(1995) PubMed=15329724; DOI=10.1038/nature02840 Daryl E. Klein, Valerie M. Nappi, Gregory T. Reeves, Stanislav Yefimovic Shvartsman, Mark Andrew Lemmon; Argos inhibits epidermal growth factor receptor signalling by ligand sequestration. Nature 430:1040-1044(2004)
Cell line databases/resources	FlyBase_Cell_line; FBtc9000067
Encyclopedic resources	Wikidata; Q107116816
Entry history
Entry creation	20-May-2021
Last entry update	14-Aug-2025
Version number	7