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Cellosaurus imWilms3 (CVCL_A5SP)

[Text version]
Cell line name imWilms3
Accession CVCL_A5SP
Resource Identification Initiative To cite this cell line use: imWilms3 (RRID:CVCL_A5SP)
Comments Population: Caucasian.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; None_reported; -; Zygosity=- (PubMed=33379206).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Val432Serfs*87 (c.1293_1294insA); Zygosity=Homozygous; Note=Somatic (PubMed=33379206).
Disease Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5SF (Wilms3)
Sex of cell Male
Age at sampling 11-12M
Category Conditionally immortalized cell line
Publications

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora;
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references
Encyclopedic resources Wikidata; Q107115460
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number10