Cellosaurus cell line Wilms5 (CVCL

Cellosaurus Wilms5 (CVCL_A5SH)

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Cell line name

Wilms5

Accession

CVCL_A5SH

Resource Identification Initiative

To cite this cell line use: Wilms5 (RRID:CVCL_A5SH)

Comments

Population: Caucasian.
Donor information: The patient has a germline WT1 p.Arg390Ter (c.1168C>T) mutation that was lost in the tumor.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Mutation; HGNC; HGNC:2514; CTNNB1; None_reported; -; Zygosity=- (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg433Profs*84 (c.1296_1299delGC); Zygosity=Homozygous; Note=Somatic (PubMed=20106868; PubMed=33379206).

Disease

Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

Category

Finite cell line

STR profile

Source(s): PubMed=33379206

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D3S1358	15,16
D5S818	10,13
D7S820	10
D8S1179	13,14
D13S317	11
D16S539	8,12
D18S51	12,16
D21S11	28,29
FGA	20,22
Penta D	11,13
Penta E	7,15
TH01	8
TPOX	9,10
vWA	17,18

Publications

PubMed=20106868; DOI=10.1093/hmg/ddq042
Brigitte Royer-Pokora, Maike Anna Busch, Manfred Beier, Constanze Duhme, Carmen de Torres, Jaume Mora, Artur Brandt, Hans-Dieter Royer;
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
Hum. Mol. Genet. 19:1651-1668(2010)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora;
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Encyclopedic resources

Wikidata; Q107117472

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number