Cellosaurus cell line Wilms4 (CVCL

Cellosaurus Wilms4 (CVCL_A5SG)

[Text version]

Cell line name

Wilms4

Accession

CVCL_A5SG

Resource Identification Initiative

To cite this cell line use: Wilms4 (RRID:CVCL_A5SG)

Comments

Population: Caucasian.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Gene deletion; HGNC; HGNC:12796; WT1; Zygosity=Heterozygous (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.His438Profs*7 (c.1311_1312insC); Zygosity=Heterozygous (PubMed=20106868; PubMed=33379206).

Disease

Wilms tumor-aniridia-genitourinary anomalies-mental retardation syndrome (NCIt: C3718)
WAGR syndrome (ORDO: Orphanet_893)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

11M

Category

Finite cell line

STR profile

Source(s): PubMed=33379206

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D3S1358	16,17
D5S818	10,12
D7S820	10,11
D8S1179	13
D13S317	8
D16S539	9,12
D18S51	16,17
D21S11	27,31.2
FGA	20
Penta D	10,12
Penta E	11,15
TH01	7,8
TPOX	8,11
vWA	15,17

Publications

PubMed=20106868; DOI=10.1093/hmg/ddq042
Brigitte Royer-Pokora, Maike Anna Busch, Manfred Beier, Constanze Duhme, Carmen de Torres, Jaume Mora, Artur Brandt, Hans-Dieter Royer;
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
Hum. Mol. Genet. 19:1651-1668(2010)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Brigitte Royer-Pokora, Maike Anna Busch, Sarah Tenbusch, Mathias Schmidt, Manfred Beier, Andrew D. Woods, Holger Thiele, Jaume Mora;
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Encyclopedic resources

Wikidata; Q107117471

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number