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Cellosaurus JMUi001-A-3 (CVCL_A5QI)

[Text version]
Cell line name JMUi001-A-3
Synonyms DSG2-KO; UKWCHFi002-A-3
Accession CVCL_A5QI
Resource Identification Initiative To cite this cell line use: JMUi001-A-3 (RRID:CVCL_A5QI)
Comments From: Comprehensive Heart Failure Center, University Clinic Wurzburg; Wurzburg; Germany.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 3049; DSG2.
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Disease Familial arrhythmogenic right ventricular dysplasia 10 (NCIt: C177248)
Familial isolated arrhythmogenic ventricular dysplasia, right dominant form (ORDO: Orphanet_293910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZL58 (JMUi001-A)
Sex of cell Male
Age at sampling 6Y
Category Induced pluripotent stem cell

PubMed=33640690; DOI=10.1016/j.scr.2021.102256
Janz A., Zink M., Cirnu A., Hartleb A., Albrecht C., Rost S., Klopocki E., Gunther K., Edenhofer F., Ergun S., Gerull B.
CRISPR/Cas9-edited PKP2 knock-out (JMUi001-A-2) and DSG2 knock-out (JMUi001-A-3) iPSC lines as an isogenic human model system for arrhythmogenic cardiomyopathy (ACM).
Stem Cell Res. 53:102256-102256(2021)

Cell line databases/resources hPSCreg; JMUi001-A-3
Encyclopedic resources Wikidata; Q107115501
Entry history
Entry creation20-May-2021
Last entry update29-Jun-2023
Version number6