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Cellosaurus JMUi001-A-2 (CVCL_A5QH)

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Cell line name JMUi001-A-2
Synonyms PKP2-KO; UKWCHFi002-A-2
Accession CVCL_A5QH
Resource Identification Initiative To cite this cell line use: JMUi001-A-2 (RRID:CVCL_A5QH)
Comments From: Comprehensive Heart Failure Center, University Clinic Wurzburg; Wurzburg; Germany.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9024; PKP2.
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Disease Familial arrhythmogenic right ventricular dysplasia 9 (NCIt: C173471)
Familial isolated arrhythmogenic ventricular dysplasia, right dominant form (ORDO: Orphanet_293910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZL58 (JMUi001-A)
Sex of cell Male
Age at sampling 6Y
Category Induced pluripotent stem cell
Publications

PubMed=33640690; DOI=10.1016/j.scr.2021.102256
Anna Janz, Miriam Zink, Alexandra Cirnu, Annika Hartleb, Christiane Albrecht, Simone Rost, Eva Klopocki, Katharina Gunther, Frank Edenhofer, Suleyman Ergun, Brenda Gerull;
CRISPR/Cas9-edited PKP2 knock-out (JMUi001-A-2) and DSG2 knock-out (JMUi001-A-3) iPSC lines as an isogenic human model system for arrhythmogenic cardiomyopathy (ACM).
Stem Cell Res. 53:102256-102256(2021)

Cross-references
Cell line databases/resources hPSCreg; JMUi001-A-2
Encyclopedic resources Wikidata; Q107115500
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number7