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Cellosaurus U2OS-ATRkd (CVCL_A5LZ)

[Text version]
Cell line name U2OS-ATRkd
Synonyms U2OS/ATRkd; U2OS ATRkd
Accession CVCL_A5LZ
Resource Identification Initiative To cite this cell line use: U2OS-ATRkd (RRID:CVCL_A5LZ)
Comments Population: Caucasian.
Transfected with: HGNC; 882; ATR (with p.Asp2494Glu = ATRkd).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line

PubMed=11481475; DOI=10.1073/pnas.161281798
Nghiem P., Park P.K., Kim Y.-S., Vaziri C., Schreiber S.L.
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation.
Proc. Natl. Acad. Sci. U.S.A. 98:9092-9097(2001)

Anatomy/cell type resources BTO; BTO:0003696
Encyclopedic resources Wikidata; Q107117180
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number5