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Cellosaurus U2OS-ATRkd (CVCL_A5LZ)

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Cell line name U2OS-ATRkd
Synonyms U2OS/ATRkd; U2OS ATRkd
Accession CVCL_A5LZ
Resource Identification Initiative To cite this cell line use: U2OS-ATRkd (RRID:CVCL_A5LZ)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:882; ATR (Note=With p.Asp2494Glu = ATRkd).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=11481475; DOI=10.1073/pnas.161281798; PMCID=PMC55378
Paul Nghiem, Peter K. Park, Yong-Son Kim, Cyrus Vaziri, Stuart Lee Schreiber;
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation.
Proc. Natl. Acad. Sci. U.S.A. 98:9092-9097(2001)

Cross-references
Anatomy/cell type resources BTO; BTO_0003696
Encyclopedic resources Wikidata; Q107117180
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number8