Cellosaurus cell line U-251MG IDH1 WT (CVCL

Cellosaurus U-251MG IDH1 WT (CVCL_A5HR)

Cross-references
Cell line name	U-251MG IDH1 WT
Synonyms	U251(WT); U251WT
Accession	CVCL_A5HR
Resource Identification Initiative	To cite this cell line use: U-251MG IDH1 WT (RRID:CVCL_A5HR)
Comments	Population: Caucasian. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5382; IDH1. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
Sequence variations	Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease	Astrocytoma (NCIt: C60781) Astrocytoma (ORDO: Orphanet_94)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0021 (U-251MG)
Sex of cell	Male
Age at sampling	75Y
Category	Cancer cell line
Publications	PubMed=33504762; DOI=10.1038/s41467-020-20752-6; PMCID=PMC7840755 Adrian Lita, Artem Pliss, Andrey N. Kuzmin, Tomohiro Yamasaki, Lu-Min Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli ...Show all 20 authors... , Michael J. Kruhlak, Thorkell Andresson, Sudipto Das, Chun-Zhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad, Mioara Larion; Show fewer authors IDH1 mutations induce organelle defects via dysregulated phospholipids. Nat. Commun. 12:614.1-614.16(2021)
Cell line databases/resources	cancercelllines; CVCL_A5HR
Encyclopedic resources	Wikidata; Q107117148
Metabolomic databases	MetaboLights; MTBLS1973
Entry history
Entry creation	20-May-2021
Last entry update	14-Aug-2025
Version number	9