Cellosaurus logo
expasy logo
Due to maintenance work, this service will be unavailable Tuesday 16 between 06:00 and 06:30 - CEST. Apologies for the inconvenience.

Cellosaurus MDA-MB-231 met2 (CVCL_A5ER)

[Text version]
Cell line name MDA-MB-231 met2
Synonyms MDA-MB-231-Met2; MDA-MB-231met2
Accession CVCL_A5ER
Resource Identification Initiative To cite this cell line use: MDA-MB-231 met2 (RRID:CVCL_A5ER)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Metastatic to lung. Established from a lung tumor after injection of the parent cell line into the tail vein of athymic nude mice (PubMed=30337562).
Transfected with: UniProtKB; P08659; Firefly luciferase (with optimized codon usage for mammalian expression).
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=30337562; DOI=10.1038/s41598-018-33453-4
Brooks H.B., Meier T.I., Geeganage S., Fales K.R., Thrasher K.J., Konicek S.A., Spencer C.D., Thibodeaux S., Foreman R.T., Hui Y.-H., Roth K.D., Qian Y.-W., Wang T., Luo S., Torrado A., Si C., Toth J.L., McCowan J.R., Frimpong K., Lee M.R., Dally R.D., Shepherd T.A., Durham T.B., Wang Y., Wu Z.-P., Iversen P.W., Njoroge F.G.
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Sci. Rep. 8:15458-15458(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5ER
Anatomy/cell type resources BTO; BTO:0006470
Encyclopedic resources Wikidata; Q107116175
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number6