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Cellosaurus MDA-MB-231 met2 (CVCL_A5ER)

[Text version]
Cell line name MDA-MB-231 met2
Synonyms MDA-MB-231-Met2; MDA-MB-231met2
Accession CVCL_A5ER
Resource Identification Initiative To cite this cell line use: MDA-MB-231 met2 (RRID:CVCL_A5ER)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Metastatic to lung. Established from a lung tumor after injection of the parent cell line into the tail vein of athymic nude mice (PubMed=30337562).
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=30337562; DOI=10.1038/s41598-018-33453-4; PMCID=PMC6193938
Harold B. Brooks, Timothy I. Meier, Sandaruwan Geeganage, Kevin R. Fales, Kenneth J. Thrasher, Susan A. Konicek, Charles D. Spencer, Stefan Thibodeaux, Robert T. Foreman, Yu-Hua Hui, Kenneth D. Roth ...Show all 27 authors... , Yue-Wei Qian, Tao Wang, Shuang Luo, Alicia Torrado, Chong Si, James L. Toth, Jefferson R. McCowan, Kwame Frimpong, Matthew R. Lee, Robert D. Dally, Timothy A. Shepherd, Timothy Barrett Durham, Yong Wang, Zhi-Pei Wu, Philip W. Iversen, F. George Njoroge; Show fewer authors
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Sci. Rep. 8:15458-15458(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5ER
Anatomy/cell type resources BTO; BTO_0006470
Encyclopedic resources Wikidata; Q107116175
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number9