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Cellosaurus JK-6L.31H (CVCL_A5DY)

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Cell line name JK-6L.31H
Accession CVCL_A5DY
Resource Identification Initiative To cite this cell line use: JK-6L.31H (RRID:CVCL_A5DY)
Comments Characteristics: Produces high quantity of IgG kappa.
Characteristics: IL6 independent.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000045116; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:7795; NFKB2; Simple; p.Arg725Glufs*18 (c.2171delC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Tyr64Asp (c.190T>G); dbSNP=rs752508313; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0C41 (JK-6L)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
Publications

PubMed=17308121; DOI=10.1158/0008-5472.CAN-06-2258
Silke Meister, Ulrich Schubert, Kirsten Neubert, Kai Herrmann, Renate Burger, Martin Gramatzki, Sabine Hahn, Sandra Schreiber, Sabine Wilhelm, Martin Herrmann, Hans-Martin Jack, Reinhard E. Voll;
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.
Cancer Res. 67:1783-1792(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5DY
Encyclopedic resources Wikidata; Q107115492
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number8