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Cellosaurus Hep-G2 VL-17A (CVCL_A5CT)

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Cell line name Hep-G2 VL-17A
Synonyms HepG2 VL-17A; VL-17A; VL17A
Accession CVCL_A5CT
Resource Identification Initiative To cite this cell line use: Hep-G2 VL-17A (RRID:CVCL_A5CT)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:2631; CYP2E1.
Genetic integration: Method=Transfection; Gene=MGI; MGI:87921; Adh1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5CQ (Hep-G2 VA-13)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=16181800; DOI=10.1016/j.biocel.2005.07.010
Terrence M. Donohue, Natalia A. Osna, Dahn L. Clemens;
Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity.
Int. J. Biochem. Cell Biol. 38:92-101(2006)

PubMed=22436864; DOI=10.1039/c2ib00155a
Karthikeyan Chandrasekaran, Kavitha Swaminathan, S. Mathan Kumar, Dahn L. Clemens, Aparajita Dey;
Increased oxidative stress and toxicity in ADH and CYP2E1 overexpressing human hepatoma VL-17A cells exposed to high glucose.
Integr. Biol. (Camb.) 4:550-563(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5CT
Anatomy/cell type resources BTO; BTO_0006458
Encyclopedic resources Wikidata; Q107115329
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number9