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Cellosaurus MCTs (CVCL_A5BF)

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Cell line name MCTs
Synonyms MCT; Mouse Chondrocytes immortalized by SV40 temperature-sensitive large T antigen
Accession CVCL_A5BF
Resource Identification Initiative To cite this cell line use: MCTs (RRID:CVCL_A5BF)
Comments Characteristics: Proliferates at the permissive temperature (32 Celsius). Dies at the restrictive temperature (37-39 Celsius) (PubMed=7822418).
Doubling time: ~2 days (Note=At 32 Celsius) (PubMed=7822418).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pZIPSVtsA58).
Derived from site: In situ; Rib, cartilage; UBERON=UBERON_0006288.
Cell type: Chondrocyte; CL=CL_0000138.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Conditionally immortalized cell line
Publications

PubMed=7822418; DOI=10.1083/jcb.128.1.239; PMCID=PMC2120322
Veronique Lefebvre, Silvio Garofalo, Benoit de Crombrugghe;
Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen.
J. Cell Biol. 128:239-245(1995)

PubMed=9990041; DOI=10.1073/pnas.96.4.1433; PMCID=PMC15480
Frank Beier, Richard J. Lee, Allison C. Taylor, Richard George Pestell, Phyllis Ann LuValle;
Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes.
Proc. Natl. Acad. Sci. U.S.A. 96:1433-1438(1999)

Cross-references
Anatomy/cell type resources BTO; BTO_0006217
Encyclopedic resources Wikidata; Q107116172
Entry history
Entry creation20-May-2021
Last entry update27-Nov-2025
Version number9