Cellosaurus cell line NCI-H838 KRAS (G12D/+9n) (CVCL

Cross-references
Cell line name	NCI-H838 KRAS (G12D/+9n)
Synonyms	KRAS (G12D/+9n) NCI-H838
Accession	CVCL_A4IK
Resource Identification Initiative	To cite this cell line use: NCI-H838 KRAS (G12D/+9n) (RRID:CVCL_A4IK)
Comments	Population: Caucasian. Characteristics: Heterozygous knockin of a KRAS activating mutation in 10 copies. Karyotypic information: Has lost chromosome Y (from parent cell line). Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Pro1876Serfs*22 (c.5625_5632del) (p.CPP1657fs) (c.5621_5628delGCCCACCA); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple_edited; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+114-002). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu62Ter (c.184G>T); ClinVar=VCV000617472; Zygosity=Homozygous (from parent cell line).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1594 (NCI-H838)
Sex of cell	Male
Age at sampling	59Y
Category	Cancer cell line
Cell line collections (Providers)	Horizon_Discovery; HD+114-002
Cell line databases/resources	cancercelllines; CVCL_A4IK
Encyclopedic resources	Wikidata; Q105510321
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	8