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Cellosaurus MCF7-Luc2 [ATCC] (CVCL_A4CI)

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Cell line name MCF7-Luc2 [ATCC]
Accession CVCL_A4CI
Resource Identification Initiative To cite this cell line use: MCF7-Luc2 [ATCC] (RRID:CVCL_A4CI)
Comments Population: Caucasian.
Characteristics: Stably expresses firefly luciferase under the control of the human EF1a promoter (ATCC=HTB-22-LUC2).
Doubling time: ~57 hours (ATCC=HTB-22-LUC2).
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression = Luc2).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-22-LUC2

Markers:
AmelogeninX
CSF1PO10
D5S81811,12
D7S8208,9
D13S31711
D16S53911,12
TH016
TPOX9,12
vWA14,15

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Cross-references
Cell line collections (Providers) ATCC; HTB-22-LUC2
Cell line databases/resources cancercelllines; CVCL_A4CI
Encyclopedic resources Wikidata; Q105510081
Entry history
Entry creation12-Jan-2021
Last entry update14-Aug-2025
Version number10