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Cellosaurus SW480-Luc2 (CVCL_A4BX)

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Cell line name SW480-Luc2
Accession CVCL_A4BX
Resource Identification Initiative To cite this cell line use: SW480-Luc2 (RRID:CVCL_A4BX)
Comments Population: Caucasian.
Characteristics: Stably expresses firefly luciferase under the control of the human EF1a promoter (ATCC=CCL-228-LUC2).
Doubling time: ~55 hours (ATCC=CCL-228-LUC2).
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression = Luc2).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0546 (SW480)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-228-LUC2

Markers:
AmelogeninX
CSF1PO13,14
D5S81813
D7S8208
D13S31712
D16S53913
TH018
TPOX11
vWA16

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Cross-references
Cell line collections (Providers) ATCC; CCL-228-LUC2
Cell line databases/resources cancercelllines; CVCL_A4BX
Encyclopedic resources Wikidata; Q105511136
Entry history
Entry creation12-Jan-2021
Last entry update14-Aug-2025
Version number11