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Cellosaurus T-47D Tam2 (CVCL_A4AP)

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Cell line name T-47D Tam2
Accession CVCL_A4AP
Resource Identification Initiative To cite this cell line use: T-47D Tam2 (RRID:CVCL_A4AP)
Comments Population: Caucasian.
Doubling time: ~1-2 weeks (ATCC=CRL-3437).
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Omics: Genomics; Whole exome sequencing.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0553 (T-47D)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3437

Markers:
AmelogeninX
CSF1PO11,13
D5S81812
D7S82011
D13S31712
D16S53910
TH016
TPOX11
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=27378269; DOI=10.1186/s12885-016-2452-5; PMCID=PMC4932681
Sara Kangaspeska, Susanne Hultsch, Alok Jaiswal, Henrik Edgren, John Patrick Mpindi, Samuli Eldfors, Oscar Bruck, Tero Aittokallio, Olli-Pekka Kallioniemi;
Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.
BMC Cancer 16:378.1-378.17(2016)

Cross-references
Cell line collections (Providers) ATCC; CRL-3437
Cell line databases/resources cancercelllines; CVCL_A4AP
Encyclopedic resources Wikidata; Q105511143
Entry history
Entry creation12-Jan-2021
Last entry update10-Apr-2025
Version number8