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Cellosaurus SK-MM-1 (CVCL_A478)

[Text version]
Cell line name SK-MM-1
Synonyms SK-MM1; SKMM-1; SKMM1; SK-MY-1; SK-My-1
Accession CVCL_A478
Resource Identification Initiative To cite this cell line use: SK-MM-1 (RRID:CVCL_A478)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 440.
Characteristics: Produces Ig kappa.
Doubling time: 32 hours (PubMed=2506399); ~48 hours (DSMZ=ACC-758).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-758; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133822,26
D3S135814,17
D5S8188,11
D7S8208,12
D8S117914
D13S31712
D16S53913,14
D18S5116,17
D19S43313
D21S1128,32
FGA24
Penta D2.2,13 (PubMed=25877200)
3,13 (DSMZ=ACC-758)
Penta E10,12
TH017
TPOX8,10
vWA18

Run an STR similarity search on this cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-multiple-myeloma-cell-line-sk-mm-1
Publications

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2506399
Omar Eton, David A. Scheinberg, Alan N. Houghton;
Establishment and characterization of two human myeloma cell lines secreting kappa light chains.
Leukemia 3:729-735(1989)

PubMed=8943038; DOI=10.1073/pnas.93.24.13931; PMCID=PMC19472
Peter Leif Bergsagel, Marta Chesi, Elena Nardini, Leslie A. Brents, Suzanne Lee Kirby, Walter Michael Kuehl;
Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma.
Proc. Natl. Acad. Sci. U.S.A. 93:13931-13936(1996)

PubMed=10557056; DOI=10.1038/sj.leu.2401563
S. Yoshida, Naozo Nakazawa, S. Iida, Yoshihito Hayami, S. Sato, Atsushi Wakita, S. Shimizu, Masafumi Taniwaki, R. Ueda;
Detection of MUM1/IRF4-IgH fusion in multiple myeloma.
Leukemia 13:1812-1816(1999)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11157491; DOI=10.1182/blood.V97.3.729
Marta Chesi, Leslie A. Brents, Sarah A. Ely, Carlos Bais, Davide F. Robbiani, Enrique A. Mesri, Walter Michael Kuehl, Peter Leif Bergsagel;
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Blood 97:729-736(2001)

PubMed=11429052; DOI=10.1111/j.1349-7006.2001.tb01142.x; PMCID=PMC5926752
Ichiro Hanamura, Shinsuke Iida, Yumiko Akano, Yoshihito Hayami, Miyuki Kato, Kazuhisa Miura, Shinsuke Harada, Shogo Banno, Atsushi Wakita, Hitoshi Kiyoi, Tomoki Naoe ...Show all 16 authors... , Shiro Shimizu, Shin-ichi Sonta, Masakazu Nitta, Masafumi Taniwaki, Ryuzo Ueda; Show fewer authors
Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations.
Jpn. J. Cancer Res. 92:638-644(2001)

PubMed=12886255; DOI=10.1038/sj.leu.2403026
Yoshihito Hayami, S. Iida, Naozo Nakazawa, Ichiro Hanamura, M. Kato, H. Komatsu, Ikuo Miura, Bhavana J. Dave, Warren G. Sanger, B. Lim, Masafumi Taniwaki, R. Ueda;
Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma.
Leukemia 17:1650-1657(2003)

PubMed=17171682; DOI=10.1002/gcc.20404
Luigia Lombardi, Giulia Poretti, Michela Mattioli, Sonia Fabris, Luca Agnelli, Silvio Bicciato, Ivo Kwee, Andrea Rinaldi, Domenica Ronchetti, Donata Verdelli, Giorgio Lambertenghi-Deliliers ...Show all 13 authors... , Francesco Bertoni, Antonino Neri; Show fewer authors
Molecular characterization of human multiple myeloma cell lines by integrative genomics: insights into the biology of the disease.
Genes Chromosomes Cancer 46:226-238(2007)

PubMed=17229644; DOI=10.3324/haematol.10300
Takaomi Sanda, Shinsuke Iida, Satoshi Kayukawa, Ryuzo Ueda;
Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid.
Haematologica 92:115-120(2007)

PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698
Jonathan J. Keats, Rafael Fonseca, Marta Chesi, Roelandt Schop, Angela Baker, Wee-Joo Chng, Scott Van Wier, Rodger Tiedemann, Chang-Xin Shi, Michael Sebag, Esteban Braggio ...Show all 30 authors... , Travis Henry, Yuan-Xiao Zhu, Homer Fogle, Tammy L. Price-Troska, Gregory J. Ahmann, Catherine Mancini, Leslie A. Brents, Shaji K. Kumar, Philip Robert Greipp, Angela Dispenzieri, Barb Bryant, George Mulligan, Laurakay Bruhn, Michael T. Barrett, Riccardo Valdez, Jeffrey M. Trent, A. Keith Stewart, John D. Carpten, Peter Leif Bergsagel; Show fewer authors
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184
Amel Dib, Ana Gabrea, Oleg K. Glebov, Peter Leif Bergsagel, Walter Michael Kuehl;
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Cell line collections (Providers) DSMZ; ACC-758
Cell line databases/resources cancercelllines; CVCL_A478
DSMZCellDive; ACC-758
SKY/M-FISH/CGH; 2544
Anatomy/cell type resources BTO; BTO_0006521
Biological sample resources BioSample; SAMN03470877
Encyclopedic resources Wikidata; Q54954407
Experimental variables resources EFO; EFO_0005457
Gene expression databases GEO; GSM143343
Polymorphism and mutation databases Cosmic; 720782
Cosmic; 760399
Cosmic; 2081407
Cosmic; 2302414
Cosmic; 2367273
Cosmic; 2391803
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number28