Cellosaurus cell line MZ-MEL-5 (CVCL

Cellosaurus MZ-MEL-5 (CVCL_A468)

[Text][XML][JSON]

Cell line name

MZ-MEL-5

Synonyms

MZ-Mel-5; Mz-Mel-5; MZ MEL 5; MZ5-MEL

Accession

CVCL_A468

Resource Identification Initiative

To cite this cell line use: MZ-MEL-5 (RRID:CVCL_A468)

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23851445).
Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (PubMed=23851445).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg15Lys (c.44G>A); ClinVar=VCV000404147; Zygosity=Unspecified (PubMed=23851445).
Mutation; HGNC; HGNC:11998; TP53; Simple; c.782+1G>C; ClinVar=VCV003148166; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=23851445).

HLA typing

Source: PubMed=15592718

Class I
HLA-A	A*32:01,26:01
HLA-B	B*07:02,57:02
HLA-C	C*07:02,06:02
Class II
HLA-DP	DPB1*04:01,04:02
HLA-DQ	DQB1*06:02,05:01
HLA-DR	DRB1*15:01,01:01

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

Age unspecified

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-056

Markers:

Amelogenin	X,Y
CSF1PO	12
D3S1358	16
D5S818	11
D7S820	8,13
D13S317	11,12
FGA	21,25
TH01	7,9.3
TPOX	8
vWA	16,17

Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Teresa Rodriguez, Rosa Mendez, Chrissy H. Roberts, Francisco Ruiz-Cabello Osuna, I. Anthony Dodi, Miguel Angel Lopez-Nevot, Laura Paco, Isabel Maleno, Steven G.E. Marsh, Graham Pawelec, Federico Garrido;
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A468
ESTDAB; ESTDAB-056

Encyclopedic resources

Wikidata; Q54907226

Polymorphism and mutation databases

Cosmic; 972269
Cosmic; 2163797

Entry history

Entry creation

06-Jun-2012

Last entry update

19-Dec-2024

Version number