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Cellosaurus NCI-H3118 (CVCL_A464)

[Text version]
Cell line name NCI-H3118
Synonyms H3118; H-3118
Accession CVCL_A464
Resource Identification Initiative To cite this cell line use: NCI-H3118 (RRID:CVCL_A464)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Gene fusion; HGNC; 16062; CRTC1 + HGNC; 16259; MAML2; Name(s)=CRTC1-MAML2, MECT1-MAML2 (PubMed=12539049).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Homozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.01
East Asian, North2.51
East Asian, South0
South Asian3.02
European, North59.54
European, South34.08
Disease Parotid gland mucoepidermoid carcinoma (NCIt: C5938)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP


Run an STR similarity search on this cell line

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=12539049; DOI=10.1038/ng1083
Tonon G., Modi S., Wu L., Kubo A., Coxon A.B., Komiya T., O'Neil K., Stover K., El-Naggar A.K., Griffin J.D., Kirsch I.R., Kaye F.J.
t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.
Nat. Genet. 33:208-213(2003)

PubMed=15193437; DOI=10.1016/j.cancergencyto.2003.10.007
Tonon G., Gehlhaus K.S., Yonescu R., Kaye F.J., Kirsch I.R.
Multiple reciprocal translocations in salivary gland mucoepidermoid carcinomas.
Cancer Genet. Cytogenet. 152:15-22(2004)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line databases/resources cancercelllines; CVCL_A464
Cell_Model_Passport; SIDM00517
Cosmic-CLP; 1240140
DepMap; ACH-002239
CRISP screens repositories BioGRID_ORCS_Cell_line; 961
Chemistry resources GDSC; 1240140
PharmacoDB; H3118_434_2019
Encyclopedic resources Wikidata; Q54908027
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1132852
GEO; GSM1132853
GEO; GSM1132854
GEO; GSM1132855
GEO; GSM1132862
GEO; GSM1132863
GEO; GSM1132864
GEO; GSM1132865
GEO; GSM1132866
GEO; GSM1132867
GEO; GSM1669832
Polymorphism and mutation databases Cosmic; 1288269
Cosmic; 1519250
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation06-Jun-2012
Last entry update30-Jan-2024
Version number25