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Cellosaurus AG876 (CVCL_A422)

[Text version]
Cell line name AG876
Synonyms Ag876; AG-876; Ag-876; AG 876; AG-876 BL; AG876BL
Accession CVCL_A422
Resource Identification Initiative To cite this cell line use: AG876 (RRID:CVCL_A422)
Comments Population: African; Ghanaian.
Virology: Contains a complete EBV genome (strain AG876) which has been sequenced (PubMed=16490228).
Doubling time: 21 hours (PubMed=8402660).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Cell type: B-cell; CL=CL_0000236.
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Publications

PubMed=205793; DOI=10.1038/272629a0
Philip A. Pizzo, Ian Trevor Magrath, Sisir K. Chattopadhyay, Robert John Biggar, Paul Gerber;
A new tumour-derived transforming strain of Epstein-Barr virus.
Nature 272:629-631(1978)

PubMed=6243721; DOI=10.1093/jnci/64.3.465
Ian Trevor Magrath, Philip A. Pizzo, Jacqueline Whang-Peng, Edwin C. Douglass, Oliver Alabaster, Paul Gerber, Charles Bryan Freeman, Ligita Novikovs;
Characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen. I Physical, cytogenetic, and growth characteristics.
J. Natl. Cancer Inst. 64:465-476(1980)

PubMed=6243722; DOI=10.1093/jnci/64.3.477
Ian Trevor Magrath, Charles Bryan Freeman, Philip A. Pizzo, James Gadek, Elaine Sarkin Jaffe, Maria Santaella, Carl Hammer, Michael M. Frank, Gregory Reaman, Ligita Novikovs;
Characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen II. Surface markers.
J. Natl. Cancer Inst. 64:477-483(1980)

PubMed=6265077
Philip A. Pizzo, Sisir K. Chattopadhyay, Ian Trevor Magrath, Eric Del Giacco, D.W. Sherrick, Thomas E. Gray;
Examination of Epstein-Barr virus and C-type proviral sequences in American and African lymphomas and derivative cell lines.
Cancer Res. 41:3165-3171(1981)

PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336
David Benjamin, Ian Trevor Magrath, Robert T. Maguire, Carol Janus, Heather D. Todd-Kulikowsk, Robert G. Parsons;
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
J. Immunol. 129:1336-1342(1982)

PubMed=3026973; DOI=10.1002/ijc.2910390215
Barbro Ehlin-Henriksson, Agneta Manneborg-Sandlund, George Klein;
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Int. J. Cancer 39:211-218(1987)

PubMed=2052620; DOI=10.1073/pnas.88.12.5413; PMCID=PMC51883
Gianluca Gaidano, Paola Ballerini, Jerry Z. Gong, Giorgio Inghirami, Antonino Neri, Elizabeth W. Newcomb, Ian Trevor Magrath, Daniel M. Knowles, Riccardo Dalla-Favera;
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

PubMed=8220424; DOI=10.1038/ng0993-56
Kishor G. Bhatia, Konrad Huppi, Gordon Spangler, David Siwarski, Radhika Iyer, Ian Trevor Magrath;
Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas.
Nat. Genet. 5:56-61(1993)

PubMed=8344493; DOI=10.1096/fasebj.7.10.8344493
Kishor G. Bhatia, Walter Goldschmidts, Marina I. Gutierrez, Gianluca Gaidano, Riccardo Dalla-Favera, Ian Trevor Magrath;
Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenetic effect.
FASEB J. 7:951-956(1993)

PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418
Vinay K. Jain, Jean-Gabriel Judde, Edward E. Max, Ian Trevor Magrath;
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
J. Immunol. 150:5418-5428(1993)

PubMed=9192833
Barry W. Cherney, Kishor G. Bhatia, Cecilia Sgadari, Marina I. Gutierrez, Howard S. Mostowski, Sandra E. Pike, Ghanshyam Gupta, Ian Trevor Magrath, Giovanna Tosato;
Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitt's lymphoma cells.
Cancer Res. 57:2508-2515(1997)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Ulf Klangby, Ismail Okan, Kristinn Petur Magnusson, Martin Wendland, Peter Lind, Klas G. Wiman;
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=9563901
Sai-Jun Fan, Barry W. Cherney, William C. Reinhold, Kimberly Rucker, Patrick M. O'Connor;
Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.
Clin. Cancer Res. 4:1047-1054(1998)

PubMed=12133989; DOI=10.4049/jimmunol.169.3.1593
Casper Paludan, Kara Bickham, Sarah Nikiforow, Ming L. Tsang, Kiera Goodman, Willem A. Hanekom, Jean-Francois Fonteneau, Stefan Stevanovic, Christian Munz;
Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells.
J. Immunol. 169:1593-1603(2002)

PubMed=16490228; DOI=10.1016/j.virol.2006.01.015
Aidan Dolan, Clare Addison, Derek Gatherer, Andrew J. Davison, Duncan James McGeoch;
The genome of Epstein-Barr virus type 2 strain AG876.
Virology 350:164-170(2006)

PubMed=24590883; DOI=10.1002/gcc.22161
Eva-Maria Murga Penas, Georgia Schilling, Petra Behrmann, Marianne Klokow, Eik Vettorazzi, Carsten Bokemeyer, Judith Dierlamm;
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

Cross-references
Encyclopedic resources Wikidata; Q54748628
Polymorphism and mutation databases Cosmic; 931115
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number19