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Cellosaurus HDC-114 (CVCL_A376)

[Text version]
Cell line name HDC-114
Synonyms HDC114
Accession CVCL_A376
Resource Identification Initiative To cite this cell line use: HDC-114 (RRID:CVCL_A376)
Comments Doubling time: 50.28 hours (PubMed=25944804).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Proteomics.
Omics: Transcriptomics; Microarray.
Misspelling: HDCC114; Cosmic=1803944.
Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
Disease Rectosigmoid carcinoma (NCIt: C7421)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO11
D5S81812
D7S82010
D13S31712
D16S53911,13
D21S1128,30
TH016,9.3
TPOX8
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=1980607; DOI=10.1002/gcc.2870020112
Silke Bruderlein, Kai van der Bosch, Peter Michael Schlag, Manfred Schwab;
Cytogenetics and DNA amplification in colorectal cancers.
Genes Chromosomes Cancer 2:63-70(1990)

PubMed=7812507; DOI=10.1007/BF00196144
Karin Koretz, Silke Bruderlein, Christof Henne, Thomas Fietz, Martin Laque, Peter Moller;
Comparative evaluation of integrin alpha- and beta-chain expression in colorectal carcinoma cell lines and in their tumours of origin.
Virchows Arch. 425:229-236(1994)

PubMed=8168998; DOI=10.1002/ijc.2910570314
Peter Moller, Karin Koretz, Frank Leithauser, Silke Bruderlein, Christof Henne, Armin Quentmeier, Peter Heinrich Krammer;
Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium.
Int. J. Cancer 57:371-377(1994)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Run-Sheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir ...Show all 20 authors... , Elaine Johnstone, Enric Domingo, David James Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M. Feller, Bernhard Kuster; Show fewer authors
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Encyclopedic resources Wikidata; Q54882140
Gene expression databases GEO; GSM1448184
Polymorphism and mutation databases Cosmic; 715203
Cosmic; 1803944
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number14