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Cellosaurus HDC-8 (CVCL_A359)

[Text version]
Cell line name HDC-8
Synonyms HDC8
Accession CVCL_A359
Resource Identification Initiative To cite this cell line use: HDC-8 (RRID:CVCL_A359)
Comments Doubling time: 52.40 hours (PubMed=25944804).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Deep proteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
Disease Rectal adenocarcinoma (NCIt: C9383)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EI73 (HDC-8NMIIK1)
Sex of cell Male
Age at sampling 81Y
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
CSF1PO12
D5S81812
D7S8208,10
D13S31711
D16S53913
D21S1131
TH019.3
TPOX8,10
vWA15,19

Run an STR similarity search on this cell line
Publications

PubMed=1980607; DOI=10.1002/gcc.2870020112
Bruderlein S., van der Bosch K., Schlag P.M., Schwab M.
Cytogenetics and DNA amplification in colorectal cancers.
Genes Chromosomes Cancer 2:63-70(1990)

PubMed=7812507; DOI=10.1007/BF00196144
Koretz K., Bruderlein S., Henne C., Fietz T., Laque M., Moller P.
Comparative evaluation of integrin alpha- and beta-chain expression in colorectal carcinoma cell lines and in their tumours of origin.
Virchows Arch. 425:229-236(1994)

PubMed=8168998; DOI=10.1002/ijc.2910570314
Moller P., Koretz K., Leithauser F., Bruderlein S., Henne C., Quentmeier A., Krammer P.H.
Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium.
Int. J. Cancer 57:371-377(1994)

PubMed=18258742; DOI=10.1073/pnas.0712176105
Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E., Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R., Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

PubMed=29101300; DOI=10.15252/msb.20177701
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line databases/resources ColonAtlas; HDC8
Encyclopedic resources Wikidata; Q54882160
Gene expression databases GEO; GSM1448104
Polymorphism and mutation databases Cosmic; 715188
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number14