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Cellosaurus SUP-B28 (CVCL_A316)

[Text version]
Cell line name SUP-B28
Synonyms AT-2; AT2
Accession CVCL_A316
Secondary accession CVCL_DI26
Resource Identification Initiative To cite this cell line use: SUP-B28 (RRID:CVCL_A316)
Comments Population: Caucasian and Pacific; Polynesian.
Doubling time: ~3 days (PubMed=12127395).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: STR profile from personal communication of Ryan, Russell James Hubbard.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (PubMed=34940123).
  • Gene fusion; HGNC; 3495; ETV6 + HGNC; 10471; RUNX1; Name(s)=ETV6-RUNX1; TEL-AML1; Note=ETV6 exon 5/RUNX1 exon 4 and RUNX1 exon 3/ETV6 exon 6 fusions (PubMed=8704231; PubMed=12127395; PubMed=34940123).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV000197243; Zygosity=Heterozygous; Note=In 50% of the reads (PubMed=34940123).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous; Note=In 3% of the reads (PubMed=34940123).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) ETV6-RUNX1 (NCIt: C80334)
B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) (ORDO: Orphanet_585929)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A314 ! SUP-B26
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133819,24
D3S135816,18
D5S81810,12
D7S82010
D8S117912,14
D13S31710
D16S5399,12
D18S5112,13
D19S43313,14
D21S1129,33.2
FGA20,24
TH019,9.3
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=8231254
Zhang L.Q., Downie P.A., Goodell W.R., McCabe N.R., Le Beau M.M., Morgan R., Sklar J., Raimondi S.C., Miley D., Goldberg A., Lu M.-M., Montag A., Smith S.D.
Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia.
Leukemia 7:1865-1874(1993)

PubMed=8704231; DOI=10.1182/blood.V88.3.785.785
Kim D.-H., Moldwin R.L., Vignon C., Bohlander S.K., Suto Y., Giordano L., Gupta R., Fears S., Nucifora G., Rowley J.D., Smith S.D.
TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.
Blood 88:785-794(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12127395; DOI=10.1016/S0165-4608(01)00655-0
Fears S., Chakrabarti S.R., Nucifora G., Rowley J.D.
Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression.
Cancer Genet. Cytogenet. 135:110-119(2002)

PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Quentmeier H., Pommerenke C., Drexler H.G.
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A316
Encyclopedic resources Wikidata; Q54750826
Gene expression databases ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039
Entry history
Entry creation06-Jun-2012
Last entry update10-Sep-2024
Version number20