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Cellosaurus SUP-B13 (CVCL_A308)

[Text version]

Cell line name SUP-B13
Synonyms SUPB13
Accession CVCL_A308
Resource Identification Initiative To cite this cell line use: SUP-B13 (RRID:CVCL_A308)
Comments Population: Caucasian.
Doubling time: ~35 hours (PubMed=1434795; PubMed=3162827).
Derived from sampling site: Bone marrow.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=3162827; PubMed=10071072).
Disease Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C68659)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0103 ! SUP-B15
Sex of cell Male
Age at sampling 9Y
Category Cancer cell line

Naumovski L., Morgan R., Hecht F., Link M.P., Glader B.E., Smith S.D.
Philadelphia chromosome-positive acute lymphoblastic leukemia cell lines without classical breakpoint cluster region rearrangement.
Cancer Res. 48:2876-2879(1988)

PubMed=1967982; DOI=10.1016/0092-8674(90)90657-Z
Nourse J., Mellentin J.D., Galili N., Wilkinson J., Stanbridge E.J., Smith S.D., Cleary M.L.
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.
Cell 60:535-545(1990)

Neely E.K., Rosenfeld R.G., Illescas A., Smith S.D.
Mitogenic effects of human recombinant insulin on B-cell precursor acute lymphoblastic leukemia cells.
Leukemia 6:1134-1142(1992)

Zhou M., Gu L., James C.D., He J., Yeager A.M., Smith S.D., Findley H.W.
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608
Zhou M., Yeager A.M., Smith S.D., Findley H.W.
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=8704231; DOI=10.1182/blood.V88.3.785.785
Kim D.-H., Moldwin R.L., Vignon C., Bohlander S.K., Suto Y., Giordano L., Gupta R., Fears S., Nucifora G., Rowley J.D.
TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.
Blood 88:785-794(1996)

PubMed=9108419; DOI=10.1182/blood.V89.8.2986
Findley H.W., Gu L., Yeager A.M., Zhou M.
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Zhou M., Gu L., Yeager A.M., Findley H.W.
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

PubMed=10071072; DOI=10.1016/s0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Encyclopedic resources Wikidata; Q54970858
Polymorphism and mutation databases Cosmic; 2348805
Entry history
Entry creation06-Jun-2012
Last entry update23-Jun-2022
Version number14