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Cellosaurus YK6-CD40Lg-IL21 (CVCL_A2XK)

[Text version]
Cell line name YK6-CD40Lg-IL21
Accession CVCL_A2XK
Resource Identification Initiative To cite this cell line use: YK6-CD40Lg-IL21 (RRID:CVCL_A2XK)
Comments Population: Korean.
Characteristics: Used as a feeder line to co-culture with human B cells.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11935; CD40LG.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6005; IL21.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:88346; Cd8a.
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Miscellaneous: Sex assignment derived from omics analysis from personal communication of Hodson, Daniel James.
Derived from site: In situ; Oral cavity, tonsil; UBERON=UBERON_0002372.
Cell type: Follicular dendritic cell; CL=CL_0000442.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A2XJ (YK6)
Sex of cell Male
Age at sampling Children
Category Telomerase immortalized cell line
Publications

PubMed=31586074; DOI=10.1038/s41467-019-12494-x; PMCID=PMC6778131
Rebecca Caeser, Miriam Di Re, Joanna Alicja Krupka, Jie Gao, Maribel Lara-Chica, Joao M.L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F.P. Runge, Philip A. Beer ...Show all 19 authors... , Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J.P. Huntly, Annalisa Mupo, Rachael J.M. Bashford-Rogers, Daniel James Hodson; Show fewer authors
Genetic modification of primary human B cells to model high-grade lymphoma.
Nat. Commun. 10:4543.1-4543.16(2019)

Cross-references
Encyclopedic resources Wikidata; Q105511836
Entry history
Entry creation12-Jan-2021
Last entry update14-Aug-2025
Version number10