| Cell line name |
MCF-10A BRCA1 (185delAG/+) |
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| Synonyms |
BRCA1 (185delAG/+) MCF10A |
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| Accession |
CVCL_A2PT |
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| Resource Identification Initiative |
To cite this cell line use: MCF-10A BRCA1 (185delAG/+) (RRID:CVCL_A2PT) |
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| Comments |
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:1100; BRCA1; Simple_edited; p.Glu23Valfs*17 (c.68_69delAG) (c.66_67AG[1]) (185delAG); ClinVar=VCV000017662; Zygosity=Heterozygous; Note=By homologous recombination (PubMed=21987798).
|
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0598 (MCF-10A) |
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| Sex of cell |
Female |
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| Age at sampling |
36Y |
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| Category |
Spontaneously immortalized cell line |
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| Publications | PubMed=21987798; DOI=10.1073/pnas.1110969108; PMCID=PMC3203756
Hiroyuki Konishi, Morassa Mohseni, Akina Tamaki, Joseph P. Garay, Sarah Croessmann, Sivasundaram Karnan, Akinobu Ota, Hong-Yuen Wong, Yuko Konishi, Bedri Karakas, Khola Tahir ...Show all 31 authors... , Abde M. Abukhdeir, John P. Gustin, Justin Cidado, Grace M. Wang, David Cosgrove, Rory Landon Cochran, Danijela Jelovac, Michaela J. Higgins, Sabrina Arena, Lauren Hawkins, Josh Lauring, Amy L. Gross, Christopher M. Heaphy, Yositaka Hosokawa, Edward W. Gabrielson, Alan K. Meeker, Kala Visvanathan, Pedram Argani, Kurtis E. Bachman, Ben Ho Park; Show fewer authors
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.
Proc. Natl. Acad. Sci. U.S.A. 108:17773-17778(2011) |
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| Cross-references |
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| Cell line collections (Providers) |
Horizon_Discovery; HD+101-018
|
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| Encyclopedic resources |
Wikidata; Q105510071
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| Entry history |
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| Entry creation | 12-Jan-2021 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 9 |
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