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Cellosaurus MDCK cMDR1-KO (CVCL_A2JX)

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Cell line name MDCK cMDR1-KO
Synonyms MDCKcMDR1-KO; MDCK II cMdr1 KO Cl2; cMdr1 KO Cl2
Accession CVCL_A2JX
Resource Identification Initiative To cite this cell line use: MDCK cMDR1-KO (RRID:CVCL_A2JX)
Comments Knockout cell: Method=CRISPR/Cas9; VGNC; VGNC:37431; ABCB1.
Omics: Proteomics; Quantitative.
Caution: Incorrectly indicated as originating from MDCK-II while it seems to be derived from MDCK.2.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Cell type: Epithelial cell of kidney; CL=CL_0002518.
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
Hierarchy Parent: CVCL_B034 (MDCK.2)
Children:
CVCL_A2KC (MDCK-hBCRP cMDR1-KO)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=26869442; DOI=10.1016/S0022-3549(15)00171-9
Ivailo Simoff, Maria Karlgren, Maria Backlund, Anne-Christine Lindstrom, Fabienne Zdenka Gaugaz, Par Matsson, Per Artursson;
Complete knockout of endogenous Mdr1 (Abcb1) in MDCK cells by CRISPR-Cas9.
J. Pharm. Sci. 105:1017-1021(2016)

PubMed=33007277; DOI=10.1016/j.xphs.2020.09.039
Christine Wegler, Meryem Gazit, Karolina Issa, Sujay Subramaniam, Per Artursson, Maria Karlgren;
Expanding the efflux in vitro assay toolbox: a CRISPR-Cas9 edited MDCK cell line with human BCRP and completely lacking canine MDR1.
J. Pharm. Sci. 110:388-396(2021)

Cross-references
Encyclopedic resources Wikidata; Q105510090
Proteomic databases PRIDE; PXD020238
Entry history
Entry creation12-Jan-2021
Last entry update10-Apr-2025
Version number10