Cellosaurus cell line SiBBE (CVCL

Cellosaurus SiBBE (CVCL_A2HP)

Cross-references
Cell line name	SiBBE
Accession	CVCL_A2HP
Resource Identification Initiative	To cite this cell line use: SiBBE (RRID:CVCL_A2HP)
Comments	Population: Southeast Asian; Thai. Doubling time: 17 hours (PubMed=33033327). Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Mononuclear cell; CL=CL_0000842.
Sequence variations	Mutation; HGNC; HGNC:4827; HBB; Simple; p.His3His (c.9T>C); ClinVar=VCV000193106; Zygosity=Heterozygous (PubMed=33033327). Mutation; HGNC; HGNC:4827; HBB; Simple; p.Glu27Lys (c.79G>A) (E26K); ClinVar=VCV000015161; Zygosity=Heterozygous (PubMed=33033327). Mutation; HGNC; HGNC:4827; HBB; Simple; c.315+16G>C; ClinVar=VCV000256345; Zygosity=Heterozygous (PubMed=33033327). Mutation; HGNC; HGNC:4827; HBB; Simple; c.316-185C>T; ClinVar=VCV000036316; Zygosity=Homozygous (PubMed=33033327).
Disease	Beta thalassemia (NCIt: C34375) Beta-thalassemia major (ORDO: Orphanet_231214)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Category	Transformed cell line
Publications	PubMed=33033327; DOI=10.1038/s41598-020-73991-4; PMCID=PMC7546635 Kongtana Trakarnsanga, Chartsiam Tipgomut, Chanatip Metheetrairut, Methichit Wattanapanitch, Archrob Khuhapinant, Saiphon Poldee, Ryo Kurita, Yukio Nakamura, Chatchawan Srisawat, Jan Frayne; Generation of an immortalised erythroid cell line from haematopoietic stem cells of a haemoglobin E/beta-thalassemia patient. Sci. Rep. 10:16798.1-16798.9(2020)
Encyclopedic resources	Wikidata; Q105511084
Entry history
Entry creation	12-Jan-2021
Last entry update	14-Aug-2025
Version number	10