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Cellosaurus MBA72R (CVCL_A2FZ)

[Text version]
Cell line name MBA72R
Accession CVCL_A2FZ
Resource Identification Initiative To cite this cell line use: MBA72R (RRID:CVCL_A2FZ)
Comments Selected for resistance to: ChEBI; CHEBI_91367; Barasertib-HQPA (AZD1152-HQPA).
Miscellaneous: Age/sex of donor and metastatic site from personal communication of Guida, Gabriella.
Derived from site: Metastatic; Right temple; UBERON=UBERON_8480027.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6929; MC1R; Simple; p.Val92Met (c.274G>A); ClinVar=VCV000014308; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6929; MC1R; Simple; p.Asp294His (c.880G>C); ClinVar=VCV000014307; Zygosity=Heterozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A2FY (MBA72)
Sex of cell Male
Age at sampling 82Y
Category Cancer cell line
Publications

DOI=10.1186/1479-5876-12-S1-P7
Amalia Azzariti, Letizia Porcelli, Anna Elisa Quatrale, Letizia Sidella, Rosa Maria Iacobazzi, Gabriella Guida, Immacolata Maida, Tiziana Cocco, Anna Ferretta, Sabino Strippoli, Stefania Guida ...Show all 14 authors... , Stefania Tommasi, Angelo Paradiso, Michele Guida; Show fewer authors
Barasertib: a novel approach for the treatment of metastatic melanoma.
J. Transl. Med. 12 Suppl. 1:P7-P7(2014)

PubMed=25623468; DOI=10.1186/s12967-015-0385-4; PMCID=PMC4314759
Letizia Porcelli, Gabriella Guida, Anna Elisa Quatrale, Tiziana Cocco, Letizia Sidella, Immacolata Maida, Rosa Maria Iacobazzi, Anna Ferretta, Diana Antonella Stolfa, Sabino Strippoli, Stefania Guida ...Show all 14 authors... , Stefania Tommasi, Michele Guida, Amalia Azzariti; Show fewer authors
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.
J. Transl. Med. 13:26.1-26.13(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2FZ
Encyclopedic resources Wikidata; Q105510040
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number7