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Cellosaurus KTC1res.1 (CVCL_A2CS)

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Cell line name KTC1res.1
Synonyms KTC1res_1; Res.1 KTC1
Accession CVCL_A2CS
Resource Identification Initiative To cite this cell line use: KTC1res.1 (RRID:CVCL_A2CS)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_63637; Vemurafenib (Zelboraf; PLX4032).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=29156680).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=29156680).
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Lys443Glu (c.1327A>G); Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=29156680).
  • Mutation; HGNC; HGNC:9801; RAC1; Simple; p.Asp63Val (c.188A>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
Disease Poorly differentiated thyroid gland carcinoma (NCIt: C6040)
Thyroid carcinoma (ORDO: Orphanet_100088)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6300 (KTC-1)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
Publications

PubMed=29156680; DOI=10.18632/oncotarget.21262; PMCID=PMC5689570
Zeus Andreas Antonello, Nancy Hsu, Manoj Bhasin, Giovanni Roti, Mukta Joshi, Paul Van Hummelen, Emily Ye, Agnes S. Lo, S. Ananth Karumanchi, Christine Roberts Bryke, Carmelo Nucera;
Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAF(V600E).
Oncotarget 8:84743-84760(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2CS
Encyclopedic resources Wikidata; Q105509839
Polymorphism and mutation databases Cosmic; 2755723
Entry history
Entry creation12-Jan-2021
Last entry update10-Apr-2025
Version number8