Cellosaurus cell line OX-CO-2 R2 Cetux (CVCL

Cross-references
Cell line name	OX-CO-2 R2 Cetux
Synonyms	OXCO-2 R2 Cetux
Accession	CVCL_A2CI
Resource Identification Initiative	To cite this cell line use: OX-CO-2 R2 Cetux (RRID:CVCL_A2CI)
Comments	Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Ile491Met (c.1473A>G); ClinVar=VCV001404733; Zygosity=Heterozygous; Note=Acquired during resistance selection process (PubMed=25623215).
Disease	Colon carcinoma (NCIt: C4910)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_2H53 (OX-CO-2)
Sex of cell	Male
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821 Sabrina Arena, Beatriz Bellosillo, Giulia Siravegna, Alejandro Martinez, Israel Canadas, Luca Lazzari, Noelia Ferruz, Mariangela Russo, Sandra Misale, Iria Gonzalez, Mar Iglesias ...Show all 25 authors... , Elena Gavilan, Giorgio Corti, Sebastijan Hobor, Giovanni Crisafulli, Marta Salido, Juan Sanchez, Alba Dalmases, Joaquim Bellmunt, Gianni De Fabritiis, Ana Rovira, Federica Di Nicolantonio, Joan Albanell, Alberto Bardelli, Clara Montagut; Show fewer authors Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer. Clin. Cancer Res. 21:2157-2166(2015)
Encyclopedic resources	Wikidata; Q105510526
Polymorphism and mutation databases	Cosmic; 2841377
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	6