| Cell line name |
NCI-H508 R2 Cetux |
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| Synonyms |
NCIH508 R2 Cetux |
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| Accession |
CVCL_A2CG |
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| Resource Identification Initiative |
To cite this cell line use: NCI-H508 R2 Cetux (RRID:CVCL_A2CG) |
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| Comments |
Population: Caucasian.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Abdominal wall; UBERON=UBERON_0003697. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly596Arg (c.1786G>C); ClinVar=VCV000375943; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
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| Disease |
Cecum adenocarcinoma (NCIt: C5543) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1564 (NCI-H508) |
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| Sex of cell |
Male |
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| Age at sampling |
55Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Sabrina Arena, Beatriz Bellosillo, Giulia Siravegna, Alejandro Martinez, Israel Canadas, Luca Lazzari, Noelia Ferruz, Mariangela Russo, Sandra Misale, Iria Gonzalez, Mar Iglesias ...Show all 25 authors... , Elena Gavilan, Giorgio Corti, Sebastijan Hobor, Giovanni Crisafulli, Marta Salido, Juan Sanchez, Alba Dalmases, Joaquim Bellmunt, Gianni De Fabritiis, Ana Rovira, Federica Di Nicolantonio, Joan Albanell, Alberto Bardelli, Clara Montagut; Show fewer authors
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A2CG
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| Encyclopedic resources |
Wikidata; Q105510319
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| Polymorphism and mutation databases |
Cosmic; 2841374
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| Entry history |
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| Entry creation | 12-Jan-2021 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 6 |
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