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Cellosaurus DiFi R1 Cetux (CVCL_A2BW)

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Cell line name DiFi R1 Cetux
Accession CVCL_A2BW
Resource Identification Initiative To cite this cell line use: DiFi R1 Cetux (RRID:CVCL_A2BW)
Comments Population: Caucasian.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu443fs*16 (c.1328_1329delAA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu1151Ter (c.3451G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Arg (c.395A>G); ClinVar=VCV000376625; Zygosity=Homozygous (from parent cell line).
Disease Colorectal carcinoma (NCIt: C2955)
Gardner syndrome (NCIt: C6728)
Gardner syndrome (ORDO: Orphanet_79665)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6895 (DiFi)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
Publications

PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Sabrina Arena, Beatriz Bellosillo, Giulia Siravegna, Alejandro Martinez, Israel Canadas, Luca Lazzari, Noelia Ferruz, Mariangela Russo, Sandra Misale, Iria Gonzalez, Mar Iglesias ...Show all 25 authors... , Elena Gavilan, Giorgio Corti, Sebastijan Hobor, Giovanni Crisafulli, Marta Salido, Juan Sanchez, Alba Dalmases, Joaquim Bellmunt, Gianni De Fabritiis, Ana Rovira, Federica Di Nicolantonio, Joan Albanell, Alberto Bardelli, Clara Montagut; Show fewer authors
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2BW
Encyclopedic resources Wikidata; Q105506752
Polymorphism and mutation databases Cosmic; 2841361
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number6