| Cell line name |
CCK-81 R3 Cetux |
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| Synonyms |
CCK81 R3 Cetux |
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| Accession |
CVCL_A2BV |
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| Resource Identification Initiative |
To cite this cell line use: CCK-81 R3 Cetux (RRID:CVCL_A2BV) |
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| Comments |
Population: Japanese.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029. |
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| Sequence variations |
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Cys420Arg (c.1258T>C); ClinVar=VCV000031945; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:667; RHOA; Simple; p.Arg5Gln (c.14G>A); ClinVar=VCV000376520; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:667; RHOA; Simple; p.Tyr42Cys (c.125A>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278His (c.833C>A); ClinVar=VCV000376646; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2873 (CCK-81) |
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| Sex of cell |
Female |
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| Age at sampling |
62Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Sabrina Arena, Beatriz Bellosillo, Giulia Siravegna, Alejandro Martinez, Israel Canadas, Luca Lazzari, Noelia Ferruz, Mariangela Russo, Sandra Misale, Iria Gonzalez, Mar Iglesias ...Show all 25 authors... , Elena Gavilan, Giorgio Corti, Sebastijan Hobor, Giovanni Crisafulli, Marta Salido, Juan Sanchez, Alba Dalmases, Joaquim Bellmunt, Gianni De Fabritiis, Ana Rovira, Federica Di Nicolantonio, Joan Albanell, Alberto Bardelli, Clara Montagut; Show fewer authors
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A2BV
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| Encyclopedic resources |
Wikidata; Q105506591
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| Polymorphism and mutation databases |
Cosmic; 2841359
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| Entry history |
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| Entry creation | 12-Jan-2021 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 8 |
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