| Cell line name |
CCK-81 R1 Cetux |
|---|
| Synonyms |
CCK81 R1 Cetux |
|---|
| Accession |
CVCL_A2BT |
|---|
| Resource Identification Initiative |
To cite this cell line use: CCK-81 R1 Cetux (RRID:CVCL_A2BT) |
|---|
| Comments |
Population: Japanese.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027. |
|---|
| Sequence variations |
- Mutation; HGNC; 3236; EGFR; Simple; p.Ser464Leu (c.1391C>T); Zygosity=Heterozygous; Note=Acquired during resistance selection process (PubMed=25623215).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Cys420Arg (c.1258T>C); ClinVar=VCV000031945; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Pro278His (c.833C>A); ClinVar=VCV000376646; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Colon adenocarcinoma (NCIt: C4349) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_2873 (CCK-81) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
62Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Arena S., Bellosillo B., Siravegna G., Martinez A., Canadas I., Lazzari L., Ferruz N., Russo M., Misale S., Gonzalez I., Iglesias M., Gavilan E., Corti G., Hobor S., Crisafulli G., Salido M., Sanchez J., Dalmases A., Bellmunt J., De Fabritiis G., Rovira A., Di Nicolantonio F., Albanell J., Bardelli A., Montagut C.
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_A2BT
|
|---|
| Encyclopedic resources |
Wikidata; Q105506584
|
|---|
| Polymorphism and mutation databases |
Cosmic; 2841357
|
|---|
| Entry history |
|---|
| Entry creation | 12-Jan-2021 |
|---|
| Last entry update | 05-Oct-2023 |
|---|
| Version number | 5 |
|---|
