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Cellosaurus UoC-B1 (CVCL_A296)

[Text version]
Cell line name UoC-B1
Synonyms UOC-B1; UOCB1; UoCB1
Accession CVCL_A296
Resource Identification Initiative To cite this cell line use: UoC-B1 (RRID:CVCL_A296)
Comments Population: Caucasian.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:4977; HLF + HGNC; HGNC:11633; TCF3; Name(s)=TCF3-HLF, E2A-HLF (PubMed=8164688).
  • Mutation; HGNC; HGNC:7978; NR3C1; Simple; p.Cys477_Arg478insGlyLeuGly (c.1431_1432insGGTCTGGGC); Zygosity=Heterozygous (PubMed=35124168).
Disease B acute lymphoblastic leukemia with TCF3-HLF rearrangement (NCIt: C199241)
B-lymphoblastic leukemia/lymphoma with t(17;19) (ORDO: Orphanet_641375)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 15Y6M
Category Cancer cell line
Publications

PubMed=8231254
Li Q. Zhang, Peter A. Downie, William R. Goodell, Norah R. McCabe, Michelle M. Le Beau, Rodman Morgan, Jeffrey Sklar, Susana C. Raimondi, Diane Miley, Aaron Goldberg, Min-Min Lu ...Show all 13 authors... , Anthony Montag, Stephen D. Smith; Show fewer authors
Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia.
Leukemia 7:1865-1874(1993)

PubMed=8164688; DOI=10.1128/mcb.14.5.3403-3413.1994; PMCID=PMC358705
Toshiya Inaba, Linda H. Shapiro, Tetsunori Funabiki, Anne E. Sinclair, Bart G. Jones, Richard A. Ashmun, Alfred Thomas Look;
DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.
Mol. Cell. Biol. 14:3403-3413(1994)

PubMed=7630190
Mu-Xiang Zhou, Lu-Bing Gu, Charles David James, J. He, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Gail Stranks, Susan E. Height, Paul Mitchell, Dalal Mouneimne Jadayel, Martin A.R. Yuille, Corinne F.M. De Lord, Robyn D. Clutterbuck, Jennie G. Treleaven, Ray Leonard Powles, Elisabeth Nacheva, David G. Oscier ...Show all 17 authors... , Abraham Karpas, Gilbert Marcel Lenoir, Stephen D. Smith, John L. Millar, Daniel Catovsky, Martin John Swinnerton Dyer; Show fewer authors
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608
Mu-Xiang Zhou, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=8704231; DOI=10.1182/blood.V88.3.785.785
Do-Hyun Kim, Richard L. Moldwin, Clementine Vignon, Stefan Klaus Bohlander, Yoshimasa Suto, Lisa Giordano, Rajat Gupta, Scott Fears, Giuseppina Nucifora, Janet Davison Rowley, Stephen D. Smith;
TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.
Blood 88:785-794(1996)

PubMed=9108419; DOI=10.1182/blood.V89.8.2986
Harry W. Findley Jr., Lu-Bing Gu, Andrew M. Yeager, Mu-Xiang Zhou;
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Mu-Xiang Zhou, Lu-Bing Gu, Andrew M. Yeager, Harry W. Findley Jr.;
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=20147975; DOI=10.1038/leu.2010.8
Koshi Akahane, T. Inukai, T. Inaba, H. Kurosawa, Alfred Thomas Look, Nobutaka Kiyokawa, J. Fujimoto, H. Goto, M. Endo, X. Zhang, K. Hirose ...Show all 17 authors... , Itaru Kuroda, Hiroko Honna, Keiko Kagami, Kumiko Goi, Shinpei Nakazawa, K. Sugita; Show fewer authors
Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.
Leukemia 24:865-869(2010)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Kinuko Hirose, Takeshi Inukai, Jiro Kikuchi, Yusuke Furukawa, Tomokatsu Ikawa, Hiroshi Kawamoto, S. Helen Oram, Berthold Gottgens, Nobutaka Kiyokawa, Yoshitaka Miyagawa, Hajime Okita ...Show all 22 authors... , Koshi Akahane, Xiao-Chun Zhang, Itaru Kuroda, Hiroko Honna, Keiko Kagami, Kumiko Goi, Hidemitsu Kurosawa, Alfred Thomas Look, Hirotaka Matsui, Toshiya Inaba, Kanji Sugita; Show fewer authors
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455
Takeshi Inukai, Xiu-Ru Zhang, Takeshi Kameyama, Yukiko Suzuki, Kazuhito Yoshikawa, Itaru Kuroda, Atsushi Nemoto, Koshi Akahane, Hiroki Sato, Kumiko Goi, Kazunori Nakamoto ...Show all 15 authors... , Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Kanji Sugita; Show fewer authors
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=31305009; DOI=10.1002/cam4.2356; PMCID=PMC6718581
Atsushi Watanabe, Takeshi Inukai, Keiko Kagami, Masako Abe, Masatoshi Takagi, Takashi Fukushima, Hiroko Fukushima, Toru Nanmoku, Kiminori Terui, Tatsuya Ito, Tsutomu Toki ...Show all 29 authors... , Etsuro Ito, Junya Fujimura, Hiroaki Goto, Mikiya Endo, Thomas Look, Mark P. Kamps, Masayoshi Minegishi, Junko Takita, Toshiya Inaba, Hiroyuki Takahashi, Akira Ohara, Daisuke Harama, Tamao Shinohara, Shinpei Somazu, Hiroko Oshiro, Koshi Akahane, Kumiko Goi, Kanji Sugita; Show fewer authors
Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Cancer Med. 8:5274-5288(2019)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4513110
ChEMBL-Targets; CHEMBL4513133
PubChem_Cell_line; CVCL_A296
Encyclopedic resources Wikidata; Q54991245
Gene expression databases GEO; GSM236810
GEO; GSM236846
GEO; GSM3145575
GEO; GSM3145744
Polymorphism and mutation databases Cosmic; 1524827
IARC_TP53; 28429
Entry history
Entry creation06-Jun-2012
Last entry update14-Aug-2025
Version number22