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Cellosaurus UoC-B1 (CVCL_A296)

[Text version]
Cell line name UoC-B1
Synonyms UOC-B1; UOCB1; UoCB1
Accession CVCL_A296
Resource Identification Initiative To cite this cell line use: UoC-B1 (RRID:CVCL_A296)
Comments Population: Caucasian.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 4977; HLF + HGNC; 11633; TCF3; Name(s)=TCF3-HLF, E2A-HLF (PubMed=8164688).
  • Mutation; HGNC; 7978; NR3C1; Simple; p.Cys477_Arg478insGlyLeuGly (c.1431_1432insGGTCTGGGC); Zygosity=Heterozygous (PubMed=35124168).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 15Y6M
Category Cancer cell line
Publications

PubMed=8231254
Zhang L.Q., Downie P.A., Goodell W.R., McCabe N.R., Le Beau M.M., Morgan R., Sklar J., Raimondi S.C., Miley D., Goldberg A., Lu M.-M., Montag A., Smith S.D.
Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia.
Leukemia 7:1865-1874(1993)

PubMed=8164688; DOI=10.1128/mcb.14.5.3403-3413.1994
Inaba T., Shapiro L.H., Funabiki T., Sinclair A.E., Jones B.G., Ashmun R.A., Look A.T.
DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.
Mol. Cell. Biol. 14:3403-3413(1994)

PubMed=7630190
Zhou M.-X., Gu L.-B., James C.D., He J., Yeager A.M., Smith S.D., Findley H.W.
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893
Stranks G., Height S.E., Mitchell P., Jadayel D.M., Yuille M.A.R., De Lord C., Clutterbuck R.D., Treleaven J.G., Powles R.L., Nacheva E., Oscier D.G., Karpas A., Lenoir G.M., Smith S.D., Millar J.L., Catovsky D., Dyer M.J.S.
Deletions and rearrangement of CDKN2 in lymphoid malignancy.
Blood 85:893-901(1995)

PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608
Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W.
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=8704231; DOI=10.1182/blood.V88.3.785.785
Kim D.-H., Moldwin R.L., Vignon C., Bohlander S.K., Suto Y., Giordano L., Gupta R., Fears S., Nucifora G., Rowley J.D., Smith S.D.
TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.
Blood 88:785-794(1996)

PubMed=9108419; DOI=10.1182/blood.V89.8.2986
Findley H.W., Gu L.-B., Yeager A.M., Zhou M.-X.
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Zhou M.-X., Gu L.-B., Yeager A.M., Findley H.W.
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20147975; DOI=10.1038/leu.2010.8
Akahane K., Inukai T., Inaba T., Kurosawa H., Look A.T., Kiyokawa N., Fujimoto J., Goto H., Endo M., Zhang X., Hirose K., Kuroda I., Honna H., Kagami K., Goi K., Nakazawa S., Sugita K.
Specific induction of CD33 expression by E2A-HLF: the first evidence for aberrant myeloid antigen expression in ALL by a fusion transcription factor.
Leukemia 24:865-869(2010)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H., Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H., Akahane K., Zhang X.-C., Kuroda I., Honna H., Kagami K., Goi K., Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

PubMed=20575032; DOI=10.1002/ajh.21738
Inukai T., Zhang X.-R., Kameyama T., Suzuki Y., Yoshikawa K., Kuroda I., Nemoto A., Akahane K., Sato H., Goi K., Nakamoto K., Hamada J.-i., Tada M., Moriuchi T., Sugita K.
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H., Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T., Sugita K., Hosoi H.
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4513110
ChEMBL-Targets; CHEMBL4513133
PubChem_Cell_line; CVCL_A296
Encyclopedic resources Wikidata; Q54991245
Gene expression databases GEO; GSM236810
GEO; GSM236846
GEO; GSM3145744
Polymorphism and mutation databases Cosmic; 1524827
IARC_TP53; 28429
Entry history
Entry creation06-Jun-2012
Last entry update30-Jan-2024
Version number19