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Cellosaurus KCL034 (CVCL_A267)

[Text version]
Cell line name KCL034
Synonyms KCL-034
Accession CVCL_A267
Resource Identification Initiative To cite this cell line use: KCL034 (RRID:CVCL_A267)
Comments Group: Clinical grade pluripotent cell line.
From: King's College London; London; United Kingdom.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-14-0268.
Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC11-54.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Donor information: Embryo is sibling to that giving rise to KCL033 (Cellosaurus=CVCL_A266).
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
HLA typing Source: PubMed=23161805
Class I
HLA-AA*11,29
HLA-BB*44,51
HLA-CC*16,04
Class II
HLA-DRDRB1*04:07,07
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Blastocyst stage
Category Embryonic stem cell
Web pages https://www.kcl.ac.uk/lsm/research/divisions/wh/groups/medicine/hescell.aspx
Publications

PubMed=23161805; DOI=10.1002/emmm.201201973
Jacquet L., Stephenson E.L., Collins R., Patel H., Trussler J., Al-Bedaery R., Renwick P., Ogilvie C.M., Vaughan R., Ilic D.
Strategy for the creation of clinical grade hESC line banks that HLA-match a target population.
EMBO Mol. Med. 5:10-17(2013)

PubMed=25122690; DOI=10.5966/sctm.2014-0015
Devito L.G., Petrova A., Miere C., Codognotto S., Blakely N., Lovatt A., Ogilvie C.M., Khalaf Y., Ilic D.
Cost-effective master cell bank validation of multiple clinical-grade human pluripotent stem cell lines from a single donor.
Stem Cells Transl. Med. 3:1116-1124(2014)

PubMed=26607962; DOI=10.1038/srep17258
Canham M.A., Van Deusen A.L., Brison D.R., De Sousa P.A., Downie J.M., Devito L.G., Hewitt Z.A., Ilic D., Kimber S.J., Moore H.D., Murray H., Kunath T.
The molecular karyotype of 25 clinical-grade human embryonic stem cell lines.
Sci. Rep. 5:17258-17258(2015)

PubMed=27345810; DOI=10.1016/j.scr.2015.12.034
Devito L.G., Jacquet L., Petrova A., Miere C., Wood V., Kadeva N., Cornwell G., Codognotto S., Stephenson E.L., Ilic D.
Generation of KCL034 clinical grade human embryonic stem cell line.
Stem Cell Res. 16:184-188(2016)

PubMed=28445466; DOI=10.1038/nature22312
Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C.
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources ISCR; 1888
NIHhESC; NIHhESC-14-0268
Encyclopedic resources Wikidata; Q54899681
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number22