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Cellosaurus KCL031 (CVCL_A264)

[Text version]
Cell line name KCL031
Synonyms KCL-031
Accession CVCL_A264
Resource Identification Initiative To cite this cell line use: KCL031 (RRID:CVCL_A264)
Comments Group: Clinical grade pluripotent cell line.
From: King's College London; London; United Kingdom.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-14-0263.
Registration: UK Stem Cell Bank (UKSCB); C-16-011, Steering comm. appl. SCSC11-58-(d).
Omics: Genomics; Whole exome sequencing.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
HLA typing Source: PubMed=23161805
Class I
HLA-AA*02,24
HLA-BB*51,52:01/04/07/13
HLA-CC*14:01/07N/11/14,12:02/17/22/30
Class II
HLA-DRDRB1*11,15
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Blastocyst stage
Category Embryonic stem cell
Web pages Provider; KCL; -; https://www.kcl.ac.uk/research/stem-cell-research
Provider; NIBSC; -; https://nibsc.org/science_and_research/advanced_therapies/uk_stem_cell_bank/cell_line_catalogue/research_grade_stem_cell_lines.aspx
Publications

PubMed=23161805; DOI=10.1002/emmm.201201973; PMCID=PMC3569650
Laureen Jacquet, Emma L. Stephenson, Robert Collins, Heema Patel, Jane Trussler, Roaa Al-Bedaery, Pamela J. Renwick, Caroline Mackie Ogilvie, Robert Vaughan, Dusko Ilic;
Strategy for the creation of clinical grade hESC line banks that HLA-match a target population.
EMBO Mol. Med. 5:10-17(2013)

PubMed=26607962; DOI=10.1038/srep17258; PMCID=PMC4660465
Maurice A. Canham, Amy Lynnette Van Deusen, Daniel Roy Brison, Paul Alexandre De Sousa, Janet M. Downie, Liani Gasparini Devito, Zoe A. Hewitt, Dusko Ilic, Susan J. Kimber, Harry D. Moore, Helen Murray, Tilo Kunath;
The molecular karyotype of 25 clinical-grade human embryonic stem cell lines.
Sci. Rep. 5:17258.1-17258.13(2015)

PubMed=27345813; DOI=10.1016/j.scr.2015.12.033; PMCID=PMC4757722
Laureen Jacquet, Victoria Wood, Neli Kadeva, Glenda Cornwell, Stefano Codognotto, Carl Hobbs, Emma L. Stephenson, Dusko Ilic;
Generation of KCL031 clinical grade human embryonic stem cell line.
Stem Cell Res. 16:195-198(2016)

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Florian T. Merkle, Sulagna Ghosh, Nolan Kamitaki, Jana Mitchell, Yishai Avior, Curtis Mello, Seva Kashin, Shila Mekhoubad, Dusko Ilic, Maura Charlton, Genevieve Saphier ...Show all 17 authors... , Robert E. Handsaker, Giulio Genovese, Shiran Bar, Nissim Benvenisty, Steven A. McCarroll, Kevin Carl Eggan; Show fewer authors
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources NIHhESC; NIHhESC-14-0263
Encyclopedic resources Wikidata; Q54899677
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number23