Cellosaurus cell line Ma-Mel-86b (CVCL

Cellosaurus Ma-Mel-86b (CVCL_A222)

Cross-references
Cell line name	Ma-Mel-86b
Synonyms	Ma-Mel_86b; Ma-Mel 86b
Accession	CVCL_A222
Resource Identification Initiative	To cite this cell line use: Ma-Mel-86b (RRID:CVCL_A222)
Comments	Characteristics: Has lost HLA class I surface expression due to the deletion of B2M (PubMed=27261508). Omics: Transcriptomics; Microarray. Omics: Variations; SNP array analysis. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Gene deletion; HGNC; HGNC:914; B2M; Zygosity=Homozygous (PubMed=27261508). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=16827748; PubMed=27261508). Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24His (c.71G>A); ClinVar=VCV000016929; Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:6840; MAP2K1; Simple; p.Pro193Ser (c.577C>T); dbSNP=rs1595884713; Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn212fs (c.633_645delAGATCCTCAGTTT); Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.741_742delinsTT) (c.741_742CC>TT); ClinVar=VCV000437017; Zygosity=Unspecified (PubMed=27261508).
Disease	Cutaneous nodular melanoma (NCIt: C4225)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A221 ! Ma-Mel-86a CVCL_C7TP ! Ma-Mel-86c CVCL_C7TQ ! Ma-Mel-86f
Sex of cell	Female
Age at sampling	35Y
Category	Cancer cell line
Publications	PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x Keith S. Hoek, Natalie C. Schlegel, Patricia Brafford, Antje Sucker, Selma Ugurel, Rajiv Kumar, Barbara L. Weber, Katherine L. Nathanson, Donald J. Phillips, Meenhard Herlyn, Dirk Schadendorf, Reinhard Dummer; Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment Cell Res. 19:290-302(2006) PubMed=27261508; DOI=10.1158/0008-5472.CAN-16-0008 Fang Zhao, Antje Sucker, Susanne Horn, Christina Heeke, Nicola Bielefeld, Barbara Schrors, Anne Bicker, Monika Lindemann, Alexander Roesch, Gustav Gaudernack, Mathias Stiller ...Show all 17 authors... , Jurgen C. Becker, Volker Lennerz, Thomas Wolfel, Dirk Schadendorf, Klaus Georg Griewank, Annette Paschen; Show fewer authors Melanoma lesions independently acquire T-cell resistance during metastatic latency. Cancer Res. 76:4347-4358(2016)
Cell line databases/resources	cancercelllines; CVCL_A222
Encyclopedic resources	Wikidata; Q54903861
Gene expression databases	GEO; GSM109093 GEO; GSM2135604
Polymorphism and mutation databases	Progenetix; CVCL_A222
Entry history
Entry creation	06-Jun-2012
Last entry update	10-Apr-2025
Version number	15