Cellosaurus cell line LB21 (CVCL

Cross-references
Cell line name	LB21
Synonyms	PARK8-LB21
Accession	CVCL_A1YE
Resource Identification Initiative	To cite this cell line use: LB21 (RRID:CVCL_A1YE)
Comments	Population: Japanese. Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:18618; LRRK2; Simple; p.Ile2020Thr (c.6059C>T); ClinVar=VCV000001941; Zygosity=Heterozygous (PubMed=26056228).
Disease	Parkinson disease 8, autosomal dominant (NCIt: C198605) Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A1YD ! LB16
Sex of cell	Female
Age at sampling	78Y
Category	Induced pluripotent stem cell
Publications	PubMed=26056228; DOI=10.1093/hmg/ddv212 Etsuro Ohta, Tomoko Nihira, Akiko Uchino, Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Kayoko Takahashi, Hideki Hayakawa, Makiko Nagai, Manabu Ohyama, Masafuchi Ryo ...Show all 19 authors... , Mieko Ogino, Shigeo Murayama, Akihiko Takashima, Kazutoshi Nishiyama, Yoshikuni Mizuno, Hideki Mochizuki, Fumiya Obata, Hideyuki Okano; Show fewer authors I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3beta signaling pathway. Hum. Mol. Genet. 24:4879-4900(2015)
Cell line databases/resources	SKIP; SKIP000994
Encyclopedic resources	Wikidata; Q105509854
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	6