Cellosaurus cell line UACC62-RMR (CVCL

Cellosaurus UACC62-RMR (CVCL_A1VN)

Cross-references
Cell line name	UACC62-RMR
Synonyms	UACC62 RMR; UACC62 SKIN CJ1
Accession	CVCL_A1VN
Resource Identification Initiative	To cite this cell line use: UACC62-RMR (RRID:CVCL_A1VN)
Comments	Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_75045; Dabrafenib (Tafinlar; GSK2118436). Selected for resistance to: ChEBI; CHEBI_75998; Trametinib (Mekinist; GSK1120212). Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (DepMap=ACH-002004). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Pro248Thrfs*5 (c.741dupA) (c.741_742insA); ClinVar=VCV000142259; Zygosity=Homozygous (DepMap=ACH-002004).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1780 (UACC-62)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=31882401; DOI=10.1158/0008-5472.CAN-19-2330; PMCID=PMC7029677 Johannes C. Melms, Sreeram Vallabhaneni, Caitlin Elizabeth Mills, Clarence Yapp, Jia-Yun Chen, Eugenio Morelli, Patricia Waszyk, Sushil Kumar, Derrick Deming, Nienke Moret, Steven Rodriguez ...Show all 24 authors... , Kartik Subramanian, Meri Rogava, Adam N.R. Cartwright, Adrienne Luoma, Shao-Lin Mei, Titus Josef Brinker, David M. Miller, Alexander Spektor, Dirk Schadendorf, Nicolo Riggi, Kai W. Wucherpfennig, Peter Karl Sorger, Benjamin Izar; Show fewer authors Inhibition of haspin kinase promotes cell-intrinsic and extrinsic antitumor activity. Cancer Res. 80:798-810(2020)
Cell line databases/resources	cancercelllines; CVCL_A1VN Cell_Model_Passport; SIDM01416 DepMap; ACH-002004
Encyclopedic resources	Wikidata; Q105511311
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	7