Cellosaurus cell line RVH-421 Dab-R (CVCL

Cross-references
Cell line name	RVH-421 Dab-R
Synonyms	RVH421_Dab; RVH421 SKIN FV1; RVH421SKINFV1
Accession	CVCL_A1VM
Resource Identification Initiative	To cite this cell line use: RVH-421 Dab-R (RRID:CVCL_A1VM)
Comments	Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_75045; Dabrafenib (Tafinlar; GSK2118436). Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (DepMap=ACH-002461). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln52fs*71 (c.154delC); Zygosity=Heterozygous (DepMap=ACH-002461).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1672 (RVH-421)
Sex of cell	Male
Age at sampling	28Y
Category	Cancer cell line
Cell line databases/resources	cancercelllines; CVCL_A1VM DepMap; ACH-002461
Encyclopedic resources	Wikidata; Q105510831
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	9