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Cellosaurus HT-144 Dab-R (CVCL_A1VJ)

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Cell line name HT-144 Dab-R
Synonyms HT144_Dab; HT144 SKIN FV1; HT144SKINFV1
Accession CVCL_A1VJ
Resource Identification Initiative To cite this cell line use: HT-144 Dab-R (RRID:CVCL_A1VJ)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_75045; Dabrafenib (Tafinlar; GSK2118436).
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (DepMap=ACH-002458).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0318 (HT-144)
Sex of cell Male
Age at sampling 29Y
Category Cancer cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_A1VJ
DepMap; ACH-002458
Encyclopedic resources Wikidata; Q105509481
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number8