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Cellosaurus HCC1569 GDC-0941_resistant (CVCL_A1FP)

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Cell line name HCC1569 GDC-0941_resistant
Accession CVCL_A1FP
Resource Identification Initiative To cite this cell line use: HCC1569 GDC-0941_resistant (RRID:CVCL_A1FP)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_65326; Pictrelisib (Pictilisib; GDC-0941).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Asn1100Thr (c.3299A>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Val1862fs*1 (c.5578delA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3701; FHIT; Simple; p.Val97Phe (c.289G>T) (651G>T); dbSNP=rs139666727; Zygosity=Heterozygous; Note=Germline (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu294Ter (c.880G>T); ClinVar=VCV000379471; Zygosity=Heterozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1255 (HCC1569)
Sex of cell Female
Age at sampling 70Y
Category Cancer cell line
Publications

PubMed=26759240; DOI=10.1158/0008-5472.CAN-15-2201
Yoshito Nakanishi, Kimberly Walter, Jill M. Spoerke, Carol O'Brien, Ling Y. Huw, Garret M. Hampton, Mark R. Lackner;
Activating mutations in PIK3CB confer resistance to PI3K inhibition and define a novel oncogenic role for p110beta.
Cancer Res. 76:1193-1203(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1FP
Encyclopedic resources Wikidata; Q102114105
Entry history
Entry creation29-Oct-2020
Last entry update14-Aug-2025
Version number9