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Cellosaurus SUM52PE GDC-0941_resistant (CVCL_A1FM)

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Cell line name SUM52PE GDC-0941_resistant
Accession CVCL_A1FM
Resource Identification Initiative To cite this cell line use: SUM52PE GDC-0941_resistant (RRID:CVCL_A1FM)
Comments Selected for resistance to: ChEBI; CHEBI_65326; Pictrelisib (Pictilisib; GDC-0941).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala68Val (c.203C>T); ClinVar=VCV000406701; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (from parent cell line).
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3425 (SUM52PE)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=26759240; DOI=10.1158/0008-5472.CAN-15-2201
Yoshito Nakanishi, Kimberly Walter, Jill M. Spoerke, Carol O'Brien, Ling Y. Huw, Garret M. Hampton, Mark R. Lackner;
Activating mutations in PIK3CB confer resistance to PI3K inhibition and define a novel oncogenic role for p110beta.
Cancer Res. 76:1193-1203(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1FM
Encyclopedic resources Wikidata; Q102114951
Polymorphism and mutation databases Cosmic; 2787233
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number7