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Cellosaurus MDA-T269 (CVCL_A1CU)

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Cell line name MDA-T269
Accession CVCL_A1CU
Resource Identification Initiative To cite this cell line use: MDA-T269 (RRID:CVCL_A1CU)
Comments Doubling time: 97.4 hours (PubMed=34147031).
Miscellaneous: Age of donor from personal communication of Henderson, Ying C.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly13Arg (c.37G>C); ClinVar=VCV000035554; Zygosity=Heterozygous (PubMed=34147031).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=34147031).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): PubMed=34147031

Markers:
AmelogeninX
CSF1PO11,14
D5S81812
D7S82010
D13S31711,12
D16S53911,13
TH016
TPOX8,11
vWA14,17

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Publications

PubMed=34147031; DOI=10.1210/clinem/dgab453; PMCID=PMC8530744
Anastasios Maniakas, Ying C. Henderson, Hu Hei, Shao-Hua Peng, Yun-Yun Chen, Yu-Jie Jiang, Shuang-Xi Ji, Maria Fernanda Cardenas, Yu-Lun Chiu, Diana Bell, Michelle D. Williams ...Show all 21 authors... , Marie-Claude Hofmann, Steve E. Scherer, David A. Wheeler, Naifa Lamki Busaidy, Ramona Dadu, Jennifer R. Wang, Maria E. Cabanillas, Mark Zafereo, Faye M. Johnson, Stephen Y. Lai; Show fewer authors
Novel anaplastic thyroid cancer PDXs and cell lines: expanding preclinical models of genetic diversity.
J. Clin. Endocrinol. Metab. 106:e4652-e4665(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1CU
Encyclopedic resources Wikidata; Q102114526
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number9