Cellosaurus cell line Ma-Mel-46 (CVCL

Cellosaurus Ma-Mel-46 (CVCL_A181)

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Cell line name

Ma-Mel-46

Synonyms

Ma-Mel_46; Ma-Mel 46

Accession

CVCL_A181

Resource Identification Initiative

To cite this cell line use: Ma-Mel-46 (RRID:CVCL_A181)

Comments

Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=16827748; PubMed=17311103; PubMed=23348503).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

51Y

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-214

Markers:

Amelogenin	X
CSF1PO	10
D3S1358	15
D5S818	12
D7S820	8,10
D13S317	11
FGA	19,25
TH01	7
TPOX	8
vWA	18,19

Publications

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Keith S. Hoek, Natalie C. Schlegel, Patricia Brafford, Antje Sucker, Selma Ugurel, Rajiv Kumar, Barbara L. Weber, Katherine L. Nathanson, Donald J. Phillips, Meenhard Herlyn, Dirk Schadendorf, Reinhard Dummer;
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595
Selma Ugurel, Ranjit K. Thirumaran, Sandra Bloethner, Andreas Gast, Antje Sucker, Jan Mueller-Berghaus, Werner Rittgen, Kari Hemminki, Jurgen C. Becker, Rajiv Kumar, Dirk Schadendorf;
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
PLoS ONE 2:e236.1-e236.13(2007)

PubMed=23348503; DOI=10.1126/science.1230062
Susanne Horn, Adina Figl, P. Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar;
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A181
ESTDAB; ESTDAB-214

Encyclopedic resources

Wikidata; Q54903803

Gene expression databases

GEO; GSM109067

Polymorphism and mutation databases

Cosmic; 1846627
Cosmic; 2686413

Entry history

Entry creation

06-Jun-2012

Last entry update

10-Apr-2025

Version number