Cellosaurus cell line Ma-Mel-46 (CVCL

Cellosaurus Ma-Mel-46 (CVCL_A181)

[Text version]

Cell line name

Ma-Mel-46

Synonyms

Ma-Mel_46; Ma-Mel 46

Accession

CVCL_A181

Resource Identification Initiative

To cite this cell line use: Ma-Mel-46 (RRID:CVCL_A181)

Comments

Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=16827748; PubMed=17311103; PubMed=23348503).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

51Y

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-214

Markers:

Amelogenin	X
CSF1PO	10
D3S1358	15
D5S818	12
D7S820	8,10
D13S317	11
FGA	19,25
TH01	7
TPOX	8
vWA	18,19

Publications

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595
Ugurel S., Thirumaran R.K., Bloethner S., Gast A., Sucker A., Mueller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R., Schadendorf D.
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
PLoS ONE 2:e236.1-e236.13(2007)

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A181
ESTDAB; ESTDAB-214

Encyclopedic resources

Wikidata; Q54903803

Gene expression databases

GEO; GSM109067

Polymorphism and mutation databases

Cosmic; 1846627
Cosmic; 2686413

Entry history

Entry creation

06-Jun-2012

Last entry update

10-Apr-2025

Version number