Cellosaurus cell line Ma-Mel-22 (CVCL

Cellosaurus Ma-Mel-22 (CVCL_A159)

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Cell line name

Ma-Mel-22

Accession

CVCL_A159

Resource Identification Initiative

To cite this cell line use: Ma-Mel-22 (RRID:CVCL_A159)

Comments

Derived from site: Metastatic; Kidney; UBERON=UBERON_0002113.

Sequence variations

Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=17311103; PubMed=23348503).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

78Y

Category

Cancer cell line

STR profile

Source(s): ECACC=13012452

Markers:

Amelogenin	X
CSF1PO	10,13
D5S818	12
D7S820	10,12
D13S317	8,11
D16S539	11,14
TH01	9.3
TPOX	8,11
vWA	17,18

Publications

PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595
Selma Ugurel, Ranjit K. Thirumaran, Sandra Bloethner, Andreas Gast, Antje Sucker, Jan Mueller-Berghaus, Werner Rittgen, Kari Hemminki, Jurgen C. Becker, Rajiv Kumar, Dirk Schadendorf;
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
PLoS ONE 2:e236.1-e236.13(2007)

PubMed=23348503; DOI=10.1126/science.1230062
Susanne Horn, Adina Figl, P. Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar;
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

Cross-references

Cell line collections (Providers)

ECACC; 13012452

Cell line databases/resources

cancercelllines; CVCL_A159
ESTDAB; ESTDAB-143

Encyclopedic resources

Wikidata; Q54903770

Polymorphism and mutation databases

Cosmic; 1846603
Cosmic; 2686382

Entry history

Entry creation

06-Jun-2012

Last entry update

19-Dec-2024

Version number