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Cellosaurus Ma-Mel-11 (CVCL_A133)

[Text version]
Cell line name Ma-Mel-11
Synonyms MaMel-11; MaMel11
Accession CVCL_A133
Resource Identification Initiative To cite this cell line use: Ma-Mel-11 (RRID:CVCL_A133)
Comments Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=26909863).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=26909863).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23348503; PubMed=23851445).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Phe90_Pro95delinsLeu (c.270_284del); Zygosity=Unspecified (PubMed=23851445).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
STR profile Source(s): ESTDAB=ESTDAB-108

Markers:
AmelogeninX
CSF1PO10,11
D3S135817
D5S81810,11
D7S82010
D13S31712
FGA25,26
TH016
TPOX8
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello Osuna F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=20544847; DOI=10.1002/gcc.20785
Gast A., Scherer D., Chen B.-W., Bloethner S., Melchert S., Sucker A., Hemminki K., Schadendorf D., Kumar R.
Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study.
Genes Chromosomes Cancer 49:733-745(2010)

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=26909863; DOI=10.18632/oncotarget.7503; PMCID=PMC4941330
Xie H.-P., Rachakonda P.S., Heidenreich B., Nagore E., Sucker A., Hemminki K., Schadendorf D., Kumar R.
Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts.
Oncotarget 7:16490-16504(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A133
ESTDAB; ESTDAB-108
Anatomy/cell type resources BTO; BTO_0005339
Encyclopedic resources Wikidata; Q54903744
Gene expression databases GEO; GSM436991
Polymorphism and mutation databases Cosmic; 1467740
Cosmic; 1846578
Cosmic; 2163820
Cosmic; 2686350
Progenetix; CVCL_A133
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number23